The Fundamental mechanisms of shock

Cox, Barbara G.

A concerned group of approximately forty investigators from the United States and Canada met in Oklahoma City in 1964 to carry out experiments on animals in endotoxin shock. Nearly all of the proposed and then-current forms of therapy to prevent irreversible shock and death were attempted (J. Okla. State Med. Assoc. 59:407-484, 1966). Unfortunately, no clearly demonstrable therapeutic benefits accrued from this massive effort. However, this meeting was without historic precedence, marking the first time in which reportedly successful therapies had been attempted on a large scale. The results left most investigators puzzled and disappointed, and a pall descended over many laboratories of shock research. It seemed clear that we had failed to penetrate the hidden barriers to our understanding of the mechanisms of endotoxin shock. Even as this postmortem is laid bare eight years later,...

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